Girls Inc. is a pioneering nonprofit organization founded in 1864, dedicated to empowering girls and young women across the United States and Canada to become strong, smart, and bold leaders. Originating in the aftermath of the Civil War to support girls facing social upheaval, it has evolved over 160 years into the longest-running girls’ leadership organization, adapting continuously to the changing challenges girls face[1][3]. The organization's mission is to inspire all girls to achieve their full potential by providing mentorship, research-based programs, and supportive, pro-girl environments. Girls Inc. operates through a network of 75 affiliates reaching nearly 120,000 girls annually, offering opportunities for growth in leadership, STEM education, financial literacy, health, and self-reliance[2][5]. Key programs include the Eureka! initiative, which integrates STEM summer camps with year-round seminars and activities, and the National Scholars Program, providing scholarships to high school seniors[5]. Girls Inc. emphasizes a values-driven approach, highlighting respect for individual dignity, diversity, equity, collaboration, and accountability. Its Girls’ Bill of Rights underscores the commitment to recognizing and respecting girls’ rights and fostering an inclusive community where girls can take healthy risks to develop confidence and resilience[1][3]. Notably, Girls Inc. is recognized as a leading expert on girls’ development, leveraging extensive experience to influence advocacy and education policies aimed at removing systemic barriers to girls' success[2]. The organization’s impact is reflected in its empowerment outcomes, such as high levels of physical activity, educational aspirations, and real-life problem-solving skills among participants[6]. Currently, Girls Inc. remains a vital force in youth empowerment, driven by professional staff and volunteers who collaborate to prepare girls for lifelong leadership and positive community impact across more than 1,690 sites in North America[4][7].