Maria Branyas Morera (1907–2024) was a Spanish supercentenarian recognized by Guinness World Records as the world's oldest verified living person, reaching 117 years and 168 days before her death in August 2024.[1][2][3] Born in San Francisco, United States, to Catalan parents, she moved to Spain at age eight and lived there for the remainder of her life, witnessing major historical events including the Spanish flu of 1918, two World Wars, the Spanish Civil War (during which she worked as a nurse), the moon landing, the fall of the Berlin Wall, and COVID-19, which she contracted mildly at age 113.[3][4][5] Branyas remained remarkably healthy into extreme old age, free of cancer, cardiovascular disease, and dementia, with only minor issues like hearing loss, mobility limitations, bronchiectasis, esophageal diverticulum, and osteoarthritis in her final months; she died peacefully in her sleep.[2][3][5] She had three children and 13 great-grandchildren, maintaining strong family ties and an active social life.[4][5] A comprehensive post-mortem study published in *Cell Reports Medicine* by researchers at the Josep Carreras Leukaemia Research Institute and University of Barcelona analyzed her blood, saliva, urine, stool, DNA, epigenome, proteome, metabolome, microbiome, and immune cells—the most detailed multiomics profile of a supercentenarian to date.[1][3][5] Key findings included protective genetic variants for neuroprotection, cardioprotection, and longevity (similar to those in long-lived animals), efficient mitochondrial function, low inflammation, an youthful gut microbiome rich in bifidobacteria (linked to her daily yogurt consumption), and an epigenetic age 15–23 years younger than chronological.[1][2][3][4] Her longevity reflected a blend of genetics and lifestyle: a Mediterranean diet rich in fish, olive oil, and three daily yogurts; no smoking or alcohol; daily habits like walking, piano-playing, gardening, reading, and dog interaction; emotional stability; and avoidance of toxins and regrets.[1][2][4][5] Lead researcher Dr. Manel Esteller noted this "fascinating duality" of aging markers alongside healthy longevity signals, emphasizing that advanced age need not equate to illness.[1][3] Branyas' case offers insights into distinguishing biological aging from disease, though more research is needed.[2][5]