The *Journal of the American Medical Association* (JAMA) is a prestigious, peer-reviewed medical journal published 48 times annually by the American Medical Association (AMA). Established in 1883 with Nathan Smith Davis as its founding editor, JAMA has evolved into a leading platform for disseminating original research, reviews, and editorials across all fields of biomedicine[1]. The journal’s impact factor in 2024 is 55.0, ranking it 4th among 332 journals in the “Medicine, General & Internal” category, underscoring its high influence in the medical research community[1]. JAMA’s history reflects the broader professionalization of medicine in the United States. Initially, it served primarily AMA members and closely resembled general journalism. By the 1920s, it began rejecting lower-quality submissions, and routine peer review was institutionalized after World War II. It adopted its current title, *JAMA: The Journal of the American Medical Association*, in 1960[1]. Throughout its history, JAMA has played a critical role in elevating medical knowledge and standards, helping shape medical education and practice nationally[4][5]. The AMA itself, founded in 1847, is the largest national association representing over 190 state and specialty medical societies. Its mission includes advancing medical science, improving education, setting ethical standards, and advocating for physicians and public health. The AMA has been a powerful lobbying force in healthcare policy, influencing legislation on vaccination, medical ethics, and drug advertising[4][6][7]. Notably, JAMA and the AMA are intertwined with significant advancements in medicine and medical education, including the influence of the 1910 Flexner Report, which revolutionized medical training standards in the U.S. and Canada[5]. Today, under editor-in-chief Kirsten Bibbins-Domingo, JAMA continues to be a vital resource for clinicians, researchers, and policymakers, offering cutting-edge scientific insights and shaping the