CRISPR Breakthrough: One-Dose Gene Editing Targets Cholesterol

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#crispr #cholesterol #gene_editing #heart_disease #medicine

How a ‘one and done’ gene-editing treatment could lower cholesterol - The Washington Post

Revolutionizing Cholesterol Treatment

A groundbreaking gene-editing trial has shown that a single CRISPR-based therapy can dramatically lower cholesterol in patients, offering hope for a long-term solution to heart disease. Unlike daily medications, this “one and done” approach targets the root cause by editing genes responsible for cholesterol regulation, potentially eliminating the need for lifelong drugs.

How It Works

The experimental treatment uses CRISPR technology to disable a gene that limits the liver’s ability to remove LDL cholesterol from the bloodstream. Early results from a small group of participants revealed significant reductions in cholesterol levels, with effects lasting months after just one dose. This precision method could transform how we manage genetic risk factors for cardiovascular disease.

Future Implications

If larger trials confirm these findings, gene editing could become a standard option for high-risk patients, reducing heart attacks and strokes worldwide. This advance marks a major leap toward personalized, curative medicine for chronic conditions.

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